Drug delivery technology is one of the frontier areas of research in the field of science and technology. Considerable attention is focused on the development of controlled drug delivery systems offering the advantages of better therapeutic efficacy and easier to comply with than the conventional regimens requiring more frequent dosing. For many disease states, the ideal dosage regimen is one in which an acceptable therapeutic concentration of the drug is immediately attained at the site of action and is maintained constant for the desired duration of treatment. Thus for such dosage regimen, a biphasic drug delivery system is beneficial. Biphasic drug delivery comprise of 2 phases i.e. immediate release phase and Sustained release phase. Few approaches had been explored in this drug delivery system like Bilayer tablets, Matrix tablets, Floating matrix tablets etc. But the drawbacks are always been a definite problems for tablets while incorporating two different phases in one tablet. To overcome these problem biphasic drug delivery through capsule device is prescribed drug delivery system. Review focused on formulation aspect of Capsule-In-Capsule Technology. The purpose of this comprehensive review is to compile the work going on this delivery system. This article explains why the development and production of biphasic drug delivery system through capsule device needs to be carried out on purpose to overcome common bi-layer table and matrix tablets problems.
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